/nbg/ - NOTHINGBURGER GENERAL: “SICKENING SICKNESS SICKENS THE SICK” Edition

There is no evidence that COVID-19 is any worse than a moderate flu season

swprs.org/a-swiss-doctor-on-covid-19/

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>0.0001% chance of dying
OMG LOCK DOWN FOR ANOTHER 3 MONTHS

back in feb i got knocked out for two days sickness. i was bedridden and missreable for two days. i thinj i had diaherreha and no cough. this probably wasntcorona was it? i remember around the aame same time a bunch of friends at the skateoark i share joints and beers with also mentioning being sick or being sick back then came up in recent conversation

t. bay area

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Bump

biorxiv.org/content/10.1101/2020.04.29.069054v1.full.pdf
Thus, this mutation might be conferring resistance to protective D614-directed
antibody responses in infected people, making them more susceptible to reinfection with the
newer G614 form of the virus. Alternatively, the advantage might be related to the fact that D614
is embedded in an immunodominant ADE epitope of SARS-CoV (Wang et al., 2016), and
perhaps the G614 form can facilitate ADE. Finally, the D614G mutation is predicted to
destabilize inter-protomer S1-S2 subunit interactions in the trimer, and this may have direct
consequences for the infectivity of the virus (Fig. 4). Increased infectivity would be consistent
with rapid spread, and also the association of higher viral load with G614 that we observed in
the clinical data from Sheffield, England
>new mutation of covid that causes 240x higher viral load, and has ade so you can never become immune

>D614-directed
>newer G614 form of the virus
>D614 is embedded in an immunodominant ADE epitope of SARS-CoV (Wang et al., 2016)
>perhaps the G614 form can facilitate ADE.
>D614G mutation
>predicted to destabilize inter-protomer S1-S2 subunit interactions in the trimer,
>consequences for the infectivity of the virus (Fig. 4). Increased infectivity would be consistent
>association of higher viral load with G614 that we observed
WOW THAT SOUNDS REALLY CONVINCING!!! WISH I HAD KNOWN ALL THIS FROM THR START I WOULD HAVE GIVEN UP MY RIGHTS SOONER!! YOU GOT MY UPBOAT FRIENDO FOR REALZ!!

...shifting gears, can anyone explain why NY hospitals have been empty this entire time and laying off doctors and nurses? I thought we needed a big ship and makeshift medical tents with thousands of beds to handle hospital overcrowding. Why was there never any evidence of a pandemic?

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Jesus christ you dipshit its coming from los alamos

Okay why should I care where it’s coming from? I do not give a fuck about your appeal to authority. Why don’t you tell me what your point is?

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Why do you take this as fact? First off it’s just a Theory, it’s also not a new mutation and it’s also not a peer reviewed paper? Quit acting like the MSM

NOOOOOO WAIT TWO MORE WEEKS AND YOU WILL SEE ITS A MUTATERINO

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>Isn't it pretty obvious by now that the real happening is the totalitarian crackdown and reshaping of our societies into a "new normal" soviet globohomo faggot monstrosity? None of it makes sense. The disease seems puny according to all proper estimates, the societal reactions encouraged by the literally WHO meaningless. Whoever heard about a half-quarantine? Either you have a fucking quarantine or you don't.

>If it was about this new media invention of "flattening the curve" you'd see our states jump to it and fucking put up some factories to make respirators and hospital gear, some field hospitals etc. to get this bullshit peak over with as soon as possible. Nothing is happening though, just all political puppet fags talking about how we have to drag this out for months on end and ruin the economy to... what? Save some 85 year old diabetics that will be dead in two years anyways? Is that something to ruin every single small time business owner and spend billions of tax breaks to kike banks and corporations over?

>And then you have the shilling here. Every day happeningfags under the CIA nigger thumb spergs out in threads with their unsubstantiated rumors and bullshit that attempts to justify the globalist reaction to these sniffles. If you ask them for sources or even just some basic reason they sperg out and go instantly into ad hominem and derail mode.

>tldr. it's a fucking CIA nigger shitshow.

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This peptide had a very high level of serological reactivity (64%), and induced long term B-cell
memory responses in convalescent-phase sera from individuals infected during the original
SARS-CoV 2002 epidemic (Wang et al., 2016). Antibodies against this peptide mediate
antibody-dependent enhancement (ADE) of SARS-CoV infection by an epitope-sequence-
dependent mechanism, both in vitro, and in vivo in rhesus macaques (Wang et al., 2016). The
minimal linear core epitope for the ADE mediating antibodies in SARS-CoV was LYQDVNC
(SARS-CoV S597-603), and this peptide is immediately proximal to a peptide that is targeted by
potentially beneficial neutralizing antibodies (SARS-CoV S604-625). The ADE target peptide spans
the SARS-CoV-2 D614 site, and is identical to the equivalent region in SARS-CoV, S611-617.
Wang et al. noted proximity of this epitope to the RBD, and speculated that antibody binding
may mediate a conformational change in Spike that increases RBD-ACE2 interaction resulting
in the enhancing effect. This mechanism is notably different from the more common Fc
receptor-mediated mechanism of SARS-CoV ADE reported by others, and which occurs in both
the presence and absence of ACE2 (Jaume et al., 2011; Kam et al., 2007; Wan et al., 2020;
Wang et al., 2014; Yilla et al., 2005; Yip et al., 2016; Yip et al., 2014). Thus, based on currently
available information, there are several ways the D614G mutation may impact Spike’s
infectivity: it may improve receptor binding, fusion activation, or ADE antibody elicitation.
Another mechanism for the shift to the G614 form at later times points might simply be through
antigenic drift mediating antibody escape. If the D614G mutation in SARS-CoV-2 was
impacting neutralizing antibody sensitivity as well as, or instead of, the ADE activity observed in
the SARS-CoV study, D614G could also be mediating escape that makes individuals
susceptible to a second infection.

In English, the same gene that controls ade in Sars1 exists in covid expressed the same way.

And as an aside, you should jump off a bridge for not knowing what los alamos is while posting on Zig Forums

Anyone have anything that debunks "no immunity" ?

You used to, because it never used to happened. Apparently somewhere in England it mutated and gained ade, as of yesterday

Holy Kek! Please stop sperging out and just get to the point already!. What conclusion are you drawing from all that? Why did you post that? What implications do you think that information has, and IN YOUR OWN WORDS, how do you feel that information is relevant to this thread?

Really I’m trying to have a discussion with you despite the red flags of autism youre showing. Just try to talk like a person.

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Lol whats coming out of your ass?
Oh right MORE BULLSHIT
Get out of here unless you have the guns to kill me glowie

Since you're retarded
Covid mutated to gain ADE sometime last week and we found out about it yesterday. Since covid has ade, it can use your own previously "registered" antibodies against you on reinfection, so you will have to build new antibodies every time. Also, it will mean it is impossible to vaccinate against since the antibodies you gain from the vaccine just help it.