End of day numbers for Day 259: 31,770,071 (+276,575); 974,758 (+5,713)
— 5,031,239,216 people under lockdown orders — — 202 countries and territories infected — — 53x more confirmed deaths than swine flu (2009-2010) — — 306 vaccines and 316 treatments announced — — 5,429 genomes have been sequenced —
Neuroinvasion of SARS-CoV-2 in human, mouse brain archive.vn/QJPBG >Thread is fake if OP is a leaf, memeflag, has text, old stats/no updates, does not link to immediately preceding thread, has wrong archive links.
>The paper is good, but it won't answer more important questions: >Who actually made it? >Who deployed it? >Is the deployment planned or an accident, or a terror attack - that is terrorists obtained / took the virus from its original owner? >Where it's FIRSTLY deployed? >For what goal ultimately?
["Memories of COVID-19" github leak that Chinese citizens were arrested for]
Lungs damaged by SARS-CoV-2 may repair in 3 months depending on the damage >average age of the patients was 61 >half were former smokers >more than six in 10 were overweight or obese >56% still suffering from lung damage 3 months later >23% performed at 80% less than normal at 6 weeks, but the proportion did not improve significantly over time archive.is/JuBrT
Study: chink-made KN95 Masks are (surprise!) garbage archive.vn/b80bD
>Boris Johnson apologetically took a hammer to Britons' social lives today as he reintroduced lockdown measures in England to last possibly six months to see off a second wave of coronavirus. >Pubs and other leisure and hospitality businesses like restaurants will face a 10pm curfew from Thursday. >People working in retail, those travelling in taxis, and staff and customers in indoor hospitality will also have to wear face coverings - except while seated at a table to eat or drink. >And in a dramatic reversal of the Government's recent drive to get people back to workplaces, all office workers will be advised to work from home where they can as soon as possible. archive.is/GkCPJ
>Has Sweden's second wave begun? Cases rise in Stockholm prompting concerns over supposed 'herd immunity' archive.vn/YjMZd
Putin offers UN staff FREE DOSE (thanks doc) of Russia’s pioneering Sputnik V jab as he calls for global conference on SARS-2 vaccine archive.vn/nJ2hm
In a review paper published today, researchers put spotlight on the potential long-term neurological consequences of SARS-2, dubbing it the 'silent wave'. They are calling for urgent action to be taken to have available more accurate diagnostic tools to identify neurodegeneration early on and a long-term monitoring approach for people who have been infected with the SARS-CoV-2 virus. archive.vn/eRcgY archive.vn/msyqb
Corona is just "flu +", it's does not justify lockdowns and too many restrictions. Just put on the mask and live normal.
More people are dying because they are too scared to go to the hospital for routine checks and such. In normal year people young people dire from flu as well. so now it's little bit more.
James Robinson
[MORE]
>Boris Johnson apologetically took a hammer to Britons' social lives today as he reintroduced lockdown measures in England to last possibly six months to see off a second wave of coronavirus. >Pubs and other leisure and hospitality businesses like restaurants will face a 10pm curfew from Thursday. >People working in retail, those travelling in taxis, and staff and customers in indoor hospitality will also have to wear face coverings - except while seated at a table to eat or drink. >And in a dramatic reversal of the Government's recent drive to get people back to workplaces, all office workers will be advised to work from home where they can as soon as possible. archive.is/GkCPJ
Most infants are well even when moms are infected by SARS-2 archive.vn/fAMFs
[!] Lower zinc levels in the blood are associated with an increased risk of death in patients with SARS-2 >Lower zinc levels at admission correlate with higher inflammation in the course of infection and poorer outcome. Plasma zinc levels at admission are associated with mortality in COVID-19 in our study. Further studies are needed to assess the therapeutic impact of this association archive.vn/5e7pX
4 out of 5 people with SARS-2 develop symptoms, a review of 79 studies says >But Horovitz and other experts said the jury's still out on how many COVID-19 patients truly remain asymptomatic throughout their infection. >But after more widespread testing over a greater period of time in the United States, Horovitz believes that "the asymptomatic rate seems to be more like 40% than 20%." archive.vn/j2p3j
This is a sequence, found both in the fake RaTG13 and the reference genome for SARS-2. >pic related How's that for homology? Let's look some more.
ncbi.nlm.nih.gov/pmc/articles/PMC1280225/ >A Single Amino Acid Change in Rabies Virus Glycoprotein Increases Virus Spread and Enhances Virus Pathogenicity Now, may I remind you that a single amino acid change in SARS-2 spike protein did the same?
>SARS-2 >Krogan says that while other viruses — including HIV and the family of viruses that cause smallpox — also use filopedia as mechanisms of spreading infection, the way this virus so rapidly prompts the growth of these tentacles is highly unusual. And the shape of them, branching off the cell and each other like trees, is also apparently strange. Other infectious diseases like HIV don't cause these kinds of prolific, mutant growths. >RABIES >The results indicated SRV9 addition has activated more filopodia production and elongation, which may induce increased virus uptake from the surrounding environment. >Meanwhile, the coincidence with the behavior of VSV suggests that the Rhabdoviridae viruses possibly share the same mechanism in the process of viral reaching to the cell body. Movement along filopodia may represent an efficient infectious pathway, by which viruses can rapidly and directly reach the endocytic zones for entry into cells. Reminder that the filopodia for SARS-2 isn't "unusual" when taking Lyssaviruses into account.
>More people are dying because they are too scared to go to the hospital for routine checks and such. >In normal year people young people dire from flu as well. so now it's little bit more. [Initial influx of excess deaths can't be explained by lockdowns/lockdowns affecting frail and sickly people's access to the hospitals]
Italy: full lockdown on March 20, but the increase in excess deaths was seen since March 4 Britain: only partial lockdown on March 21, excess deaths began rising in March 21, too Netherlands: partial lockdown in March 23, excess deaths increase since March 16 France: partial lockdown on March 17, increase in excess deaths was visible in the March 11-17 period Rio de Janeiro, Brazil: Partial lockdown only in May 5, meanwhile the RADICAL increase was visible back in April Etc, etc ourworldindata.org/policy-responses-covid#stay-at-home-restrictions ourworldindata.org/excess-mortality-covid#the-economist
>The U.S. Food and Drug Administration has granted an emergency use authorization for treating suspected COVID-19 patients with a non-invasive vagus nerve stimulator. The handheld device, made by electroCore, in Basking Ridge, N.J., sends a train of electric pulses through the skin to a nerve in the neck. [1] has shown this pulse train causes airways in the lungs to open and may also have a more general anti-inflammatory effect. spectrum.ieee.org/the-human-os/biomedical/devices/handheld-vagus-nerve-stimulator-gets-emergency-approval-for-covid19-use
[conflict of interest] Vagus nerve stimulation has been demonstrated to block production of cytokines in sepsis and other medical conditions. We hypothesize that non‐invasive vagus nerve stimulation (nVNS) might provide clinical benefits in patients with respiratory symptoms similar to those associated with COVID‐19. onlinelibrary.wiley.com/doi/full/10.1111/ner.13172
Air pollution by NO2 and PM2.5 explains SARS-2 infection severity by overexpression of angiotensin-converting enzyme 2 in respiratory cells: a review archive.vn/alokR
India, Mumbai: In four frontline warriors, coronavirus-reinfection becomes more severe >These frontline warriors were asymptomatic when they contracted the infection, initially, but had to be hospitalized the second time around. >All four persons showed more symptoms during the second infection and the illness lasted longer. >"Frontline healthcare workers are exceedingly exposed to SARS-CoV-2 and re-infections are a possibility. An RT-PCR positive test does not confirm re-infection. Only whole-genome sequencing (WGS) of the viral isolates from the different episodes can confirm a re-infection," said ICGEB's Dr. Sujatha Sunil, a key author of the study. archive.vn/QnEel
Another case of reinfection after recovery from SARS-2 has been reported, this time in a healthy young military healthcare provider at a U.S. Department of Defense hospital in Virginia archive.vn/N9Qpk A Case of Early Re-infection with SARS-CoV-2 archive.vn/RThz7
SARS-2 may damage immune cells in the bone marrow archive.vn/N9Qpk Longitudinal immune profiling reveals key myeloid signatures associated with SARS-2 archive.vn/2dH1i
Prolonged SARS-CoV-2 replication in an immunocompromised patient >a case of chronic COVID-19 in a patient with lymphoma and associated B-cell immunodeficiency. Viral cultures and sequence analysis demonstrate ongoing replication of infectious SARS-CoV-2 virus for at least 119 days. The patient had three admissions related to COVID-19 over a four-month period and was treated twice with remdesivir and convalescent plasma with resolution of symptoms. The lack of seroconversion and prolonged course illustrate the importance of humoral immunity in resolving SARS-CoV-2 infection. This case highlights challenges in managing immunocompromised hosts, who may act as persistent shedders and sources of transmission. archive.vn/G53UM medrxiv.org/content/10.1101/2020.09.20.20196899v1.full.pdf
>SARS-2 may damage immune cells in the bone marrow pubmed.ncbi.nlm.nih.gov/7815541/ >Rabies virus replication in primary murine bone marrow macrophages and in human and murine macrophage-like cell lines: implications for viral persistence Hmm... Now may I remind you that the spike protein is the most likely candidate for what makes rabies so special, it's pointed out here. ncbi.nlm.nih.gov/pmc/articles/PMC1280225/ >The RV glycoprotein (G) is a major contributor to the pathogenicity of the virus The hilarious part? If I'm right, there's a clear way to stop the D614G mutation, kek. >In summary, our study provides evidence that a single amino acid exchange within the G protein of a nonpathogenic RV can result in a reversion to the pathogenic phenotype. The increase in pathogenicity is due to a significant increase in viral spread both in vitro and in vivo. Our results also indicate that the generation of a revertant RV carrying this exchange can be prevented by introducing a Ser instead of the Asn at position 194
Andrew Green
classic dead general
Carson Young
>classic dead general No, it is novel and innovative.
it's crap, as homologies go also answer or shut the fuck up about rabies already
Gabriel Baker
>novel and innovative its a classical examplel of a dead general
Lincoln Cook
>what does it signify? That we know jackshit about the virus yet, but it would explain all the rabies like behavior it has in terms of infecting, filopodia, IFN suppression and so on. >what protein does it translate to? Probably one of the newly discovered ones. archive.is/dNGHK >10 September — Surprise! A host of tantalizing new SARS-CoV-2 proteins is unveiled >Researchers have discovered nearly two dozen previously unknown proteins encoded by SARS-CoV-2 — and their role during infection is mostly mysterious. >Until now, SARS-CoV-2’s RNA genome was known to hold the instructions for making 29 proteins, such as the spike protein that helps viral particles to infect cells, and a variety of viral proteins that become active inside cells. But scientists were uncertain whether the virus had more than those 29. >what does that protein do, in this context? Most likely I would assume it's part of the immune suppresion and replication of the virus considering SARS-2 replicates unlike SARS-CoV did when blocking IFR-3 phosphorylation. >why is it important? Yeah, why would immune suppression be important?
Nah, we're just a bit crazy.
>stop acting like a fucking obsessed femoid Holy shit, you didn't even give me 4 minutes, geez, calm down there chinkoid.
Cameron Ward
why do people believe we will see a vaccine for SARS-CoV-2? we couldn't get one for SARS in like 20 years, what's changed?
Ryan Allen
>>SARS-2 may damage immune cells in the bone marrow holy fuck, the true depths of how bad this is are terrifying to consider..
Austin Rogers
>You could take some of these non-believers with you if you, they'll thank you for it in the afterlife. STOP RIGHT THERE youtu.be/TGDBuoLJ5tQ Why don't you make some tea for the incoming officers Sven?
>what's changed? People are getting increasingly retarded from the virus, both through brain damage as seen in these cureus.com/articles/38691-behavioral-changes-without-respiratory-symptoms-as-a-presenting-sign-of-covid-19-encephalitis >Behavioral Changes Without Respiratory Symptoms as a Presenting Sign of COVID-19 Encephalitis casereports.bmj.com/content/13/9/e237378 >Cerebrospinal fluid confirmed COVID-19-associated encephalitis treated successfully >On 12 May 2020, he started to become physically and verbally aggressive, as stated by his acquaintances. archive.is/HIbHv >New-onset psychosis in COVID-19 pandemic: a case series in Madrid archive.is/7lv6R >Psychiatric presentation of patients with acute SARS-CoV-2 infection: a retrospective review of 50 consecutive patients seen by a consultation-liaison psychiatry team archive.is/wYQwd >New onset psychosis and mania following COVID-19 infection >Here we present two case reports of adult patients with COVID-19 infections who presented with severe psychosis and mania with no prior psychiatric history and in the absence of significant medical or pulmonary symptoms and an unremarkable neurological work-up. As well as the fact that it's binding to ACE2 causing serotonin deficiency. pubmed.ncbi.nlm.nih.gov/29679094/ >Depletion of angiotensin-converting enzyme 2 reduces brain serotonin and impairs the running-induced neurogenic response >ACE2 metabolizes Ang II to Ang-(1-7) and is essential for the intestinal uptake of tryptophan (Trp), the 5-HT precursor. And specifically, it fucks around in the gut a lot leading to even more serotonin deficiency. archive.is/dYaEL >GI directly attacked by the virus.
Yup, and so far, rabies splicing would explain a lot and would be properly terrifying.
I've got something waiting for them alright, but it ain't tea.
Michael Diaz
it would explain all the rabies like behavior it has in terms of infecting, filopodia, IFN suppression and so on that one little sequence? my my my. very capable, eh how does it do all that? and again, which reading is the correct one, oh future Nobel winner? you only recently started paying attention to this shit, yes?
William Williams
I was here in the early days, but it was stressing me out a lot so I took a huge break from following it while isolating doing all I can to avoid catching this nightmare fuel.
I was califag in the earlier threads though
Justin Jenkins
Reminder to brush your teeth and rinse with enamel repairing mouthwash for the coming collapse when economies collapse and panic sets in from virus season
Hudson Price
No, we just called out the Health Service for classifying a 4 year old dying in a car crash 2 days after testing positive as a "Covid death"
>TODAY'S LATEST TOTALS ▶ 148 new cases and 4 new deaths in Mozambique ▶ 1,069 new cases and 14 new deaths in Germany ▶ 67 new cases in Maldives ▶ 2,249 new cases and 45 new deaths in Ecuador ▶ 231 new cases and 2 new deaths in Ireland
This. The better the state of your teeth will be, the better you will bite when it comes down to it.
so a worse virus, that was man made would be easier to create a vaccine for? this thing is a monster, and there's no way in hell a vaccine is coming.
Anthony Wright
ok, so the thing is, this virus can and does infect neurons, on top of the whole vascular damage thing, and the pancreatitis and hepatitis and the bleeding gut and whatnot (which are just endothelial issues of some sort or another) so, expect a lot of lurid shit. parkinson's. lock-in syndrome even. tourette's-like repetitive behaviors. poor impulse control in general
I wish all the weak people would finally die. They are ruining everything for normal people with lockdowns. Half the people I know have already been "infected", including myself and almost no one had any symptoms.
Camden Ward
I have guns but I've always said, you may beat me up but my goal isn't to win, I'm happy with just a nose or ear
Robert Campbell
>and again, which reading is the correct one, oh future Nobel winner? I told you I wasn't going to spoonfeed you anymore. >that one little sequence? Nope, there's a lot more which I've shown you before but as I said, I'm not gonna spoonfeed you anymore.
See, I don't really want to stop this. I don't care if I'm right about it, I'm not out for recognition or a nobel prize, it's all fluff really. I know what I know and I'm telling you guys, and if you don't want to believe me or go for the nobel prize yourself, go for it, because I sure as hell won't. The simple fact is that the virus is doing these things, like how the the SARS-CoV spike protein did not have the additional 4 charged residutes in it's S1 subunit as SARS-CoV-2 has, which seems to be allowing the it to bind to sialic acid and N-acetylglucosamine to cross the BBB by adsorptive transcytosis. Mind you, there's been lots of research done by modifying RGP peptides to cross the BBB, sort of seems like this is the case here too, desu. Then of course we've got the filopodia which you thought were like (nano) wires to connect to electricity that really doesn't have a lot of matches in terms of other viruses, neither smallpox nor HIV causes the same type of filopodia.
confirms some of what I suspected early on then.. depressing
Adam Lewis
> I told you I wasn't going to spoonfeed you anymore. you have absolutely no idea what I am talking about, do you? Can you prove at least that you understand what I am asking of you?
> there's a lot more which I've shown you before right... magic!
Mason Hall
>TODAY'S LATEST TOTALS ▶ 65,936 new cases and 663 new deaths in India ▶ 34 new cases in Belize
Survival is not your top priority? Because I don't think a nose or a ear are anyhow cool enough of a souvenir to be worthy of being brought to Valhalla.
eh. I expect most people will eventually either clear or control it, with not much in terms of short-term damage but the wave of early onset dementias is gonna be depressing yeah guess it's time to legalize weed everywhere exhibit A, the well-adjusted sociopath, ladies and gentlemen
Ethan Cooper
>you have absolutely no idea what I am talking about, do you? I think you're the one that doesn't have any idea of what you're talking about since you're so desperate for me to explain it to you. >Can you prove at least that you understand what I am asking of you? Why should I? You've never proven a single thing and keep using that very specific line all the time, why should you have all the fun? >right... magic! Exactly, sort of like you knowing all that chink slang and using it when you get mad! No wait, that was just knowing your enemy, and apparently that includes calling people in the west gweilo? archive.4plebs.org/pol/thread/268374134/#268382886 >smart enough to cook up a scheme to give the gweilo a worse virus than they accidentally unleashed upon themselves archive.4plebs.org/pol/thread/269262566/#q269270645 >I had you pinned for a baizuo, but you're just plain old wumao Maybe it's magic like this is "nonsensical bullshit"? archive.4plebs.org/pol/thread/268374134/#268376845 >>there's a three way mutation that's required for what you claim is D614G alone >nonsensical bullshit I mean, so much to choose from.
>Why should I? because it is you who claimed stuff. now you have to explain it, for other people to understand so, which one, asshole?
Elijah Morris
>because it is you who claimed stuff. now you have to explain it, for other people to understand No, you claimed it was important so why should I spoonfeed you? >so, which one, asshole? Yeah, why don't you tell all these people why it's important, you're the one that claimed it was.
Dylan White
>TODAY'S LATEST TOTALS ▶ 10 new cases in Curaçao ▶ 83 new cases and 2 new deaths in Lesotho
