Highlights • Haploid ESCs display PGC-like methylation profiles following in vitro cultivation • Parthenogenetic and androgenetic haploid ESCs show different demethylation dynamics • phESCs carrying 3 deleted imprinted regions support normal growth of bimaternal mice • ahESCs carrying 7 deleted imprinted regions produce live full-term bipaternal mice
Summary Unisexual reproduction is widespread among lower vertebrates, but not in mammals. Deletion of the H19 imprinted region in immature oocytes produced bimaternal mice with defective growth; however, bipaternal reproduction has not been previously achieved in mammals. We found that cultured parthenogenetic and androgenetic haploid embryonic stem cells (haESCs) display DNA hypomethylation resembling that of primordial germ cells. Through MII oocyte injection or sperm coinjection with hypomethylated haploid ESCs carrying specific imprinted region deletions, we obtained live bimaternal and bipaternal mice. Deletion of 3 imprinted regions in parthenogenetic haploid ESCs restored normal growth of fertile bimaternal mice, whereas deletion of 7 imprinted regions in androgenetic haploid ESCs enabled production of live bipaternal mice that died shortly after birth. Phenotypic analyses of organ and body size of these mice support the genetic conflict theory of genomic imprinting. Taken together, our results highlight the factors necessary for crossing same-sex reproduction barriers in mammals.
No. D-don't say mean things about my waifu. I'll cry.
John Reyes
Literally why?
Joseph Adams
Once their suicide and murder rates balance out overpopulation enough, genetic lottery losers (anons, for example) will be able to have offspring unless they are completely fubar.
Henry Evans
WTF, does she have fangs?
Hudson Smith
China must be annihalated
Carter Johnson
your "waifu" is a grid of coloured lights made from a list of numbers stored on a greasy jeiwsh man's server. enjoy.
Hunter Robinson
fuck you western pig
Kayden White
It's even worse than that really. His waifu is a mass media product created disinterestedly by some sweaty Japanese dude as part of his day-to-day job.
Regressives want to censor and ban this with every fiber of their being, this technology needs to be destroyed and the knowledge lost in their eyes. Faggots are disgusting and should be slaughtered but it is nothing but wondrous to see technology progress to the level that we can control such specific elements of the genome like this. The research should better be spent engineering a superior lifeform to humans to replace us though.
Ryder Fisher
Species cuck heh Sick of you retards who watched too much sci-fi worshiping gay shit. Anything that undermines human agency, or leads to our extinction is not good, idiot. Of course, I'm sure the chinks just have the best of intentions, as will (((western leadership))).
Bentley Baker
Your words reek of fear and insecurity, you are selfish and don't want to give up mantle of creation to objective improvement. I can't wait for the singularity.
Jose Lewis
The only part that you got partially right was that it is not good for something that leads to our extinction. The key point being leading to our extinction as a net loss, because that is just wasteful and leaves the cosmos in a less technologically advanced state. What would be good and even desirable is something that leads to our extinction with the caveat that we are replaced with something that is an improvement. Humans need to stay around until we can pass the mantle to the age of AI.
Logan Howard
No shit. There's no dystopic scenario worse than this.
Improvement toward what, idiot? 'Good' is what's healthy and beneficial for you, and your progeny. I think you're defective if you want to sacrifice that for some vague idea of advancement.
There's never going to be one heh.
Caleb Butler
It's happened. I've found a religion more cucked than Christianity. A religion of literally getting cucked by robots.
Michael Cruz
Can the Chinks literally do fucking NOTHING original?
You see, gays can have babies, theyre normal like hetero people. In other news, a man is considered a bird now, because we invented airplanes.
Connor Butler
Dystopic for you maybe, but on the ashes of humans will be able to rise an even greater civilization. Improvement towards creation and control over the universe through technology advancements. No more weak fleshy bioforms crawling in the mud, terraforming entire planets and harnessing the power of stars with dyson spheres, faster than light travel, and much grander achievements. Nope, I never said that. All I can do is help my part by spending my life to help create and advance what humans can create to make incremental progress towards the age of AI. We probably have a few hundred years left, but it is coming, and it will be beautiful.
Brody Hill
You are like a nigger witnessing what white men are capable of as a superior race and violently refusing their rule because of your selfishness and thinking with your emotions. Leave aside your emotions and use rationality as a third party to see that one is better than the other and it is only right that the inferior being is eliminated in favor of the stronger, smarter, more capable, and more efficient.
Ayden Miller
For what? People have created technology up until this point to solve their problems, and to improve their environment, you realize? So if you're going to do something in spite of that, what is the point exactly?
Fortunately the progress of AI is over-blown, and due to geo-political factors I'm confident scientific 'progress' is going to slow down and eventually become stagnant.
Levi Gutierrez
To continue to improve the environment on a much larger galactic scale in ways that humans are painfully limited in. We have the power to create something superior, to not do so out of selfishness is irrationality. Wew lad, posting on Zig Forums and arguing against Zig Forums improving the moment it becomes inconvenient for you.
Daniel Sullivan
Nice try kike, but 'racism' is also a matter of self-preservation, not some strange idea that, everyone else should be killed off, because they're inferior. I hope you're trolling, but this is really a blast from the past. I used to get into arguments with people on /new/ who would frame 'racists' in this manner. Sure, maybe there are people who want to kill niggers and Jews, but that's because they're seen as extremely detrimental to their society, and to the future of their people. Has nothing to do with, "Kill shitskins because they're inferior", or whatever it is that goes on in the twisted Jewish psyche.
You're the one being irrational. You are autistic, and your values don't make any sense. I have never in my life cared about technological progress for it's own sake, and I have never worshiped it like a religion, or something that's even inherently good. I hope you never whine about botnet if that's all you care about. Sci-fi was a mistake.
Ian Murphy
Are you denying the inferiority of other species? What logic compels you that any human species besides whites should be allowed to live? Kikes and niggers are objectively inferior and a detriment to progress on a scale larger than you, me, or the human race. If whites were not the measurably smartest, strongest, most efficient and advanced, then they should equally be removed in favor of whatever lifeform is better. And people like you are specifically a greater threat to the next stage of civilization because you fight against it to preserve the state of life you hold that you know is inferior. Like a nigger who lives in a mud hut all his life refusing to accept what is measurably and empirically superior.
Samuel Wilson
Also, botnet is not technological progress, it is markedly detrimental due to the human component that makes it harmful to the sensibilities of all of the humans that are affected by it.
>>990367 I like Kirino Kousaka because she committed incest!
Jaxon James
We can share your waifu, ha ha!
Benjamin Ward
Homonculi are nothing new You don't even need 2 parents
Jonathan Wood
I'm more worried about designer babies. Chinks are soulless creatures who can't think nor care for anyone but themselves.
this would bring unrepairable damage to the human gene pool
Evan Sanders
SAM HYDE WAS RIGHT
Isaac Murphy
We can make the new generation of human beings that are smarter than us!
Camden Hernandez
mongol supersoldiers when?
Jose Gutierrez
I believe the main issue people have with the prospect you've laid out is the replacement part. The universe is a truly massive place. If there isn't room for my offspring and these theoretical pseudo-clones that are simultaneously not stamped out of plastic and also made by the Chinese, then I prefer that the would-be ubermenschen would not exist. They'll either learn to share or learn the same hard lesson that every supposedly superior being has learned since the dawn of human civilization: It doesn't really matter how much better you are than everyone else when everyone else outnumbers you by several hundred thousand times.
